R18 TFA(Synonyms: PHCVPRDLSWLDLEANMCLP TFA)

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R18 TFA (Synonyms: PHCVPRDLSWLDLEANMCLP TFA) 纯度: 98.35%

R18 TFA 是 14-3-3 的肽拮抗剂，其KD 值为 70-90 nM。R18 可有效阻断14-3-3 与其配体Raf-1激酶的结合，可有效地消除14-3-3对磷酸酶诱导的Raf-1失活的保护作用。

R18 TFA(Synonyms: PHCVPRDLSWLDLEANMCLP TFA)

R18 TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥3500 In-stock
10 mg ￥6000 In-stock
50 mg   询价  
100 mg   询价  

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R18 TFA 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].

分子量

2423.73

Formula

C103H158F3N27O31S3
Sequence

Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro
Sequence Shortening

PHCVPRDLSWLDLEANMCLP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
参考文献

  • [1]. B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38(38):12499-504.

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