SGD-1882(Synonyms: PBD dimer)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SGD-1882 (Synonyms: PBD dimer) 纯度: 98.45%

SGD-1882 是一种有细胞毒性的 DNA 小沟交联剂，为 PBD 二聚体，可以作为 ADC 的有效载荷。

SGD-1882(Synonyms: PBD dimer)

SGD-1882 Chemical Structure

CAS No. : 1222490-34-7

规格 价格 是否有货 数量
1 mg ￥10500 In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

SGD-1882 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Toxins for Antibody-Drug Conjugate Research Library

生物活性

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

体外研究
(In Vitro)

SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates[1]. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

725.79

Formula

C42H39N5O7
CAS 号

1222490-34-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Eunhee G. Kim, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics. Biomol Ther (Seoul). 2015 Nov; 23(6): 493-509.

    [2]. Dowdy Jackson, et al. Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates. Pharm Res. 2015; 32(11): 3458-3469.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务