上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
M-110 纯度: 98.78%
M-110 是一种高选择性的,ATP 竞争性的 PIM 激酶抑制剂,M-110 对 PIM-3 抑制作用最好,IC50=47 nM。M-110 抑制 PIM-1 和 PIM-2 的IC50 为 2.5 μM。M-110 抑制前列腺癌细胞的增殖,IC50 为 0.6-0.9 μM。
M-110 Chemical Structure
CAS No. : 1395048-49-3
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥3575 | In-stock | |
5 mg | ¥3250 | In-stock | |
10 mg | ¥5500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
* Please select Quantity before adding items.
M-110 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Epigenetics Compound Library
- Immunology/Inflammation Compound Library
- JAK/STAT Compound Library
- Kinase Inhibitor Library
- Anti-Cancer Compound Library
- Anti-Pancreatic Cancer Compound Library
- Targeted Diversity Library
生物活性 |
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM[1]. |
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体外研究 (In Vitro) |
M-110 (0.01-10 μM; 72 hours) inhibiting the growth of DU-145 cells with an IC50 value of 0.9 μM[1]. M-110 has no activity on normal human peripheral blood mononuclear cells up to 40 μM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
Western Blot Analysis[1]
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分子量 |
445.94 |
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Formula |
C22H28ClN5O3 |
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CAS 号 |
1395048-49-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 33.33 mg/mL (74.74 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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