Chitosan (MW 150000)(Synonyms: Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000))

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Chitosan (MW 150000) (Synonyms: Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000))

Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) 是衍生自几丁质的聚阳离子线性多糖，分子量为 150000。Chitosan 因其无毒，低致敏性，生物相容性和可生物降解性而被广泛使用。Chitosan 还具有抗肿瘤，抗细菌，抗真菌和抗氧化活性。

Chitosan (MW 150000)(Synonyms: Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000))

Chitosan (MW 150000) Chemical Structure

CAS No. : 9012-76-4

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生物活性

Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities[1][2].

体外研究
(In Vitro)

Chitosan (2 mg/mL; 48 hours; SKMEL28 and RPMI7951 cells) treatment presents a reduced growth potential[1].
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment shows potent pro-apoptotic effects against RPMI7951 through the mitochondrial pathway[1].
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment induces an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL[1].
Low-molecular-weight chitosan can penetrate bacterial cell walls, bind with DNA and inhibit DNA transcription and mRNA synthesis, while high-molecular-weight Chitosan can bind to the negatively charged components on the bacterial cell wall. It forms an impermeable layer around the cell, changes cell permeability and blocks transport into the cell. Chitosan also can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity research and as a scaffold for tissue engineering[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SKMEL28 and RPMI7951 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Presented a reduced growth potential.

Apoptosis Analysis[1]

Cell Line: RPMI7951 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Had potent pro-apoptotic effects against RPMI7951.

Western Blot Analysis[1]

Cell Line: RPMI7951 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Induced an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL.

体内研究
(In Vivo)

In chemical-induced colonic precancerous lesions in ICR mice, in the 2 weeks preventive experiments, mice fed with a diet containing high molecular weight Chitosan (HMWC) had significant fewer aberrant crypt foci formation than those fed with control diet. As the treatment extended to 6 weeks, both low molecular weight Chitosan (LMWC)- and HMWC-fed mice contained less aberrant crypt foci when compared to control[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

150000.00(Average)

Formula

C18H35N3O13
CAS 号

9012-76-4
中文名称

壳聚糖 (MW 150000)；脱乙酰几丁质 (MW 150000)；聚氨基葡糖 (MW 150000)；甲壳素 (MW 150000)；几丁聚糖 (MW 150000)；脱乙酰壳多糖 (MW 150000)；脱乙酰甲壳素 (MW 150000)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Laure Gibot, et al. Anticancer properties of chitosan on human melanoma are cell line dependent. Int J Biol Macromol. 2015 Jan;72:370-9.

    [2]. Randy Chi Fai Cheung, et al. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015 Aug 14;13(8):5156-86.

    [3]. Shyr-Yi Lin, et al. Chitosan prevents the development of AOM-induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis. J Cell Biochem. 2007 Apr 15;100(6):1573-80.

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