Jervine(Synonyms: 蒜黎芦碱; 11-Ketocyclopamine)

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Jervine (Synonyms: 蒜黎芦碱; 11-Ketocyclopamine) 纯度: 99.03%

Jervine (11-Ketocyclopamine)是一种有效的刺猬 (Hh) 抑制剂，IC50 为 500-700 nM。Jervine 是来自 Veratrum album 的根茎的天然致畸性甾体生物碱。Jervine 具有抗炎和抗氧化特性。

Jervine(Synonyms: 蒜黎芦碱; 11-Ketocyclopamine)

Jervine Chemical Structure

CAS No. : 469-59-0

规格 价格 是否有货 数量
5 mg ￥810 In-stock
10 mg ￥1500 In-stock
50 mg ￥6850 In-stock
100 mg ￥12000 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties[2].

IC50 & Target

IC50: 500-700 nM (Hedgehog)[1]
体外研究
(In Vitro)

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation[3].
Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEL and TF1a cells
Concentration: 40 μM
Incubation Time: 6, 12 and 24 hours
Result: Inhibited Akt phosphorylation.

体内研究
(In Vivo)

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (180-200  g)[2]
Dosage: 50, 100, 200 and 400  mg/kg
Administration: Orally
Result: Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.

分子量

425.60

Formula

C27H39NO3
CAS 号

469-59-0
中文名称

蒜黎芦碱；介芬胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 1 mg/mL (2.35 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3496 mL 11.7481 mL 23.4962 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Williams JA, et al.Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basalcell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.

    [2]. Dumlu FA, et al.Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album.Phytomedicine. 2019 Mar 1;55:191-199.

    [3]. Ghezali L, et al.Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect.Exp Cell Res. 2013 Apr 15;319(7):1043-53.

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