Carbendazim(Synonyms: 多菌灵) | whatman (沃特曼)

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Carbendazim (Synonyms: 多菌灵) 纯度: 99.81%

Carbendazim 是一种有效的，具有口服活性的口服广谱苯并咪唑杀菌剂 (fungicide)，可作为真菌疾病研究的杀虫剂，如孢霉病、镰刀菌病和菌核病。Carbendazim 是一种具有抗肿瘤活性的苯并咪唑 (HY-Y1825) 衍生物，用于癌症研究，特别是晚期实体肿瘤和淋巴瘤。

Carbendazim Chemical Structure

CAS No. : 10605-21-7

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥550	In-stock
100 mg	￥500	In-stock
500 mg	￥700	In-stock
1 g	￥900	In-stock
5 g	￥2700	In-stock
10 g		询价
50 g		询价

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Carbendazim 相关产品

•相关化合物库:

Clinical Compound Library Plus
Bioactive Compound Library Plus
Anti-Infection Compound Library
Anti-Cancer Compound Library
Clinical Compound Library
Antifungal Compound Library
Anti-Blood Cancer Compound Library

生物活性

Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina^[1]^[3]. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma^[3].

体外研究
(In Vitro)

Carbendazim (4-60 µM; 24 hours) has no effects on viability of HeLa cells in a CCK-8 assay^[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Carbendazim (oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days) induces hepatic lipid metabolism disorder, it results in a significant increase of hepatic lipid accumulation and triglyceride (TG) levels in mice^[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week-old male ICR mice^[2]
Dosage:	100 and 500 mg/kg
Administration:	Oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days
Result:	Increased the relative mRNA levels of some key genes related to lipogenesis and TG synthesis. Up-regulated mRNA levels of IL-1b and IL-6 in the liver in mice. Increased the serum concentrations of 2 proinflammatory cytokines IL-1b and IL-6 at 500 mg/kg. However, in the fat tissues, onlyIL-1b in the CBZ-500-treated group increased significantly as compared with the control group.

Clinical Trial

分子量

191.19

Formula

C₉H₉N₃O₂

CAS 号

10605-21-7

中文名称

多菌灵

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 6.8 mg/mL (35.57 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.2304 mL	26.1520 mL	52.3040 mL
5 mM	1.0461 mL	5.2304 mL	10.4608 mL
10 mM	0.5230 mL	2.6152 mL	5.2304 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 0.5 mg/mL (2.62 mM); Clear solution

此方案可获得 ≥ 0.5 mg/mL (2.62 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 0.5 mg/mL (2.62 mM); Clear solution

此方案可获得 ≥ 0.5 mg/mL (2.62 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Carbendazim

[2]. Yuanxiang Jin, et al. Oral Exposure of Mice to Carbendazim Induces Hepatic Lipid Metabolism Disorder and Gut Microbiota Dysbiosis. Toxicol Sci. 2015 Sep;147(1):116-26

[3]. Bilge G. Tuna, et al. Enhanced antitumor activity of carbendazim on HeLa cervical cancer cells by aptamer mediated controlled release. RSC Advances

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