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RU-SKI 43 hydrochloride (Synonyms: RU-SKI 43(盐酸盐)) 纯度: 98.54%
RU-SKI 43 hydrochloride 是一种有效的选择性刺猬酰基转移酶 (Hhat) 抑制剂,IC50 为 850 nM。RU-SKI 43 hydrochloride 通过独立于平滑化的非规范信号传导降低 Gli-1 激活,并抑制 Akt 和 mTOR 通路活性。RU-SKI 43 hydrochloride 具有抗癌活性。
RU-SKI 43 hydrochloride Chemical Structure
CAS No. : 1782573-67-4
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1024 | In-stock | |
2 mg | ¥800 | In-stock | |
5 mg | ¥1100 | In-stock | |
10 mg | ¥1600 | In-stock | |
50 mg | ¥6900 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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RU-SKI 43 hydrochloride 相关产品
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生物活性 |
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity[1]. |
IC50 & Target |
IC50: 850 nM (Hhat)[1] |
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体外研究 (In Vitro) |
RU-SKI 43 hydrochloride (10 μM; for 6 days) strongly decreases cell proliferation (83% in AsPC-1 cells) in AsPC-1 and Panc-1 cells[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Western Blot Analysis[1]
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体内研究 (In Vivo) |
RU-SKI 43 hydrochloride has a t1/2 of 17 min in mouse plasma after IV administration[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
423.01 |
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Formula |
C22H31ClN2O2S |
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CAS 号 |
1782573-67-4 |
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中文名称 |
RU-SKI 43(盐酸盐) |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : ≥ 51 mg/mL (120.56 mM) H2O : 2.5 mg/mL (5.91 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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