PluriSIn #2

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PluriSIn #2  纯度: ≥98.0%

PluriSIn #2 是一种拓扑异构酶 II α (TOP2A) 的选择性转录抑制剂。PluriSIn #2 是一种选择性消除未分化的人类多能干细胞 (hPSC) 的化合物。

PluriSIn #2

PluriSIn #2 Chemical Structure

CAS No. : 56563-17-8

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PluriSIn #2 相关产品

•相关化合物库:

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生物活性

PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].

IC50 & Target[1]

topoisomerase II alpha

 

体外研究
(In Vitro)

PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1].
A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: B153 and HUES9 human pluripotent stem cells (hPSCs)
Concentration: 20 µM
Incubation Time: 12 hours
Result: Reduced TOP2A expression at the protein level.

分子量

249.20

Formula

C11H8FN3O3
CAS 号

56563-17-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : 5 mg/mL (20.06 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0128 mL 20.0642 mL 40.1284 mL
5 mM 0.8026 mL 4.0128 mL 8.0257 mL
10 mM 0.4013 mL 2.0064 mL 4.0128 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33(3):1013-9.

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