Belizatinib(Synonyms: TSR-011)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Belizatinib (Synonyms: TSR-011) 纯度: 99.66%

Belizatinib 是一种有效的，可口服的ALK 和 TRKA、TRKB、TRKC 双重抑制剂，对野生型重组 ALK 的 IC50 值为0.7 nM。

Belizatinib(Synonyms: TSR-011)

Belizatinib Chemical Structure

CAS No. : 1357920-84-3

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1271 In-stock
2 mg ￥600 In-stock
5 mg ￥1000 In-stock
10 mg ￥1600 In-stock
25 mg ￥3200 In-stock
50 mg ￥4500 In-stock
100 mg ￥6100 In-stock
200 mg   询价  
500 mg   询价  

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Belizatinib 相关产品

•相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Kinase Inhibitor Library
  • Neuronal Signaling Compound Library
  • Protein Tyrosine Kinase Compound Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Drug Repurposing Compound Library
  • Anti-Lung Cancer Compound Library

生物活性

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

IC50 & Target

IC50: 0.7 nM (ALK)[1]
体外研究
(In Vitro)

TSR-011 has antitumour activity in the clinical trials.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

577.73

Formula

C33H44FN5O3
CAS 号

1357920-84-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 300 mg/mL (519.27 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7309 mL 8.6546 mL 17.3091 mL
5 mM 0.3462 mL 1.7309 mL 3.4618 mL
10 mM 0.1731 mL 0.8655 mL 1.7309 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Sullivan I, et al. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

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