Tramiprosate(Synonyms: Homotaurine; 3-Amino-1-propanesulfonic acid)

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Tramiprosate (Synonyms: Homotaurine; 3-Amino-1-propanesulfonic acid) 纯度: ≥98.0%

Tramiprosate (Homotaurine)，一种具有口服活性和可透过血脑屏障的天然氨基酸，存在于各种红色海藻中。Tramiprosate 与可溶性 Aβ 结合并以非原纤维形式维持 Aβ。Tramiprosate 还是一种 GABA 类似物，具有神经保护，抗惊厥和抗高血压的作用。

Tramiprosate(Synonyms: Homotaurine; 3-Amino-1-propanesulfonic acid)

Tramiprosate Chemical Structure

CAS No. : 3687-18-1

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生物活性

Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].

体外研究
(In Vitro)

Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (200-250 g) subjected to middle cerebral artery occlusion (MCAO)[1]
Dosage: 50 mg/kg, 25 mg/kg, 12.5 mg/kg or 6.25 mg/kg
Administration: Intraperitoneal injection; once
Result: Dose-dependently reduced the infarct volume after MCAO.

Clinical Trial

分子量

139.17

Formula

C3H9NO3S
CAS 号

3687-18-1
中文名称

高牛磺酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 20 mg/mL (143.71 mM; Need ultrasonic)

DMSO : 1 mg/mL (7.19 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 7.1855 mL 35.9273 mL 71.8546 mL
5 mM 1.4371 mL 7.1855 mL 14.3709 mL
10 mM 0.7185 mL 3.5927 mL 7.1855 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： PBS

    Solubility: 140 mg/mL (1005.96 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.

    [2]. Francine Gervais, et al. Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiol Aging. 2007 Apr;28(4):537-47.

    [3]. R G Fariello, et al. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology. 1982 Mar;32(3):241-5.

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