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(Z)-4EGI-1 纯度: 98.01%
(Z)-4EGI-1 是 4EGI-1 的 Z-型异构体,是 eIF4E/eIF4G 相互作用和翻译起始的抑制剂。(Z)-4EGI-1 有效结合 eIF4E ,IC50 为 43.5 μM,Kd 值为 8.74 μM。(Z)-4EGI-1 具有抗癌活性。
(Z)-4EGI-1 Chemical Structure
CAS No. : 901787-88-0
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥2750 | In-stock | |
5 mg | ¥2500 | In-stock | |
10 mg | ¥3800 | In-stock | |
50 mg | ¥9500 | In-stock | |
100 mg | ¥14500 | In-stock | |
250 mg | ¥22000 | In-stock | |
500 mg | 询价 | ||
1 g | 询价 |
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(Z)-4EGI-1 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Cell Cycle/DNA Damage Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
生物活性 |
(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2]. |
IC50 & Target |
IC50: 43.5 μM (eIF4E)[2] |
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体外研究 (In Vitro) |
(Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
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分子量 |
451.28 |
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Formula |
C18H12Cl2N4O4S |
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CAS 号 |
901787-88-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (110.80 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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