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Angoline 纯度: 99.67%
Angoline 是一种有效的选择性的 IL6/STAT3 信号通路抑制剂,IC50 为 11.56 μM。Angoline 抑制 STAT3 磷酸化及其靶基因表达,并抑制癌细胞增殖。
Angoline Chemical Structure
CAS No. : 21080-31-9
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥1800 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
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Angoline 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Immunology/Inflammation Compound Library
- JAK/STAT Compound Library
- Kinase Inhibitor Library
- Stem Cell Signaling Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Differentiation Inducing Compound Library
- Anti-Breast Cancer Compound Library
- Anti-Lung Cancer Compound Library
- Anti-Pancreatic Cancer Compound Library
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- Transcription Factor Targeted Library
生物活性 |
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1]. |
IC50 & Target |
IC50: 11.56 μM (IL6/STAT3 signaling pathway) |
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分子量 |
379.41 |
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Formula |
C22H21NO5 |
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CAS 号 |
21080-31-9 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 33.33 mg/mL (87.85 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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