(S,R,S)-AHPC-C4-NH2 hydrochloride(Synonyms: VH032-C4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28)

发表于由

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(S,R,S)-AHPC-C4-NH2 hydrochloride (Synonyms: VH032-C4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28) 纯度: 95.35%

(S,R,S)-AHPC-C4-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个 linker。用于合成 EED 的靶向PROTAC。

(S,R,S)-AHPC-C4-NH2 hydrochloride(Synonyms: VH032-C4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28)

(S,R,S)-AHPC-C4-NH2 hydrochloride Chemical Structure

CAS No. : 2245697-83-8

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3850 In-stock
100 mg ￥3500 In-stock
500 mg ￥13500 询价
1 g ￥25000 询价
2 g ￥35000 询价
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

生物活性

(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1].

IC50 & Target

VHL

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

566.16

Formula

C27H40ClN5O4S
CAS 号

2245697-83-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

DMSO : ≥ 109.6 mg/mL (193.58 mM)

H2O : ≥ 50 mg/mL (88.31 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7663 mL 8.8314 mL 17.6629 mL
5 mM 0.3533 mL 1.7663 mL 3.5326 mL
10 mM 0.1766 mL 0.8831 mL 1.7663 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.

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