上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Solamargine (Synonyms: Solamargin; δ-Solanigrine) 纯度: ≥98.0%
Solamargine 是一种来源于茄属植物的类固醇 Solasodine 的衍生物,在多种癌症中均表现出抗癌活性。Solamargine 诱导非选择性细胞毒性和 P-gp 抑制作用。Solamargine 通过下调 MMP-2 和 MMP-9 的表达和活性来显着抑制 HepG2 细胞的迁移和侵袭。
![Solamargine Chemical Structure Solamargine(Synonyms: Solamargin; δ-Solanigrine)](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-n0069.gif)
Solamargine Chemical Structure
CAS No. : 20311-51-7
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
10 mM * 1 mL in DMSO | ¥1719 | In-stock | |
5 mg | ¥1200 | In-stock | |
10 mg | ¥1800 | In-stock | |
50 mg | ¥6800 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
Solamargine 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Membrane Transporter/Ion Channel Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Glycoside Compound Library
- Lipid Compound Library
- Traditional Chinese Medicine Monomer Library
- Alkaloids Library
- Food-Sourced Compound Library
生物活性 |
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity[1][2]. |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[3]
|
||||||||||||||||
体内研究 (In Vivo) |
Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo[4]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||||||
分子量 |
868.06 |
||||||||||||||||
Formula |
C45H73NO15 |
||||||||||||||||
CAS 号 |
20311-51-7 |
||||||||||||||||
中文名称 |
澳洲茄边碱;边缘茄碱 |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
|
||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (115.20 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
||||||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务