EN40

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

EN40  纯度: 95.15%

EN40 是一种有效的选择性乙醛脱氢酶 3A1 (ALDH3A1) 抑制剂,一种共价配体,IC50 值为 2 uM。

EN40

EN40 Chemical Structure

CAS No. : 2094547-67-6

规格 价格 是否有货 数量
5 mg ¥4500 In-stock
10 mg ¥7500 In-stock
25 mg ¥13500 In-stock
50 mg ¥22500 In-stock
100 mg ¥33500 In-stock
200 mg   询价  
500 mg   询价  

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EN40 相关产品

相关化合物库:

  • Bioactive Compound Library Plus

生物活性

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM[1]

IC50 & Target

IC50: 2 uM (ALDH3A1)[1]

体外研究
(In Vitro)

EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 10 μM; 100 μM; 1000 μM
Incubation Time: 48 hours
Result: Inhibited A549 cells survival.

体内研究
(In Vivo)

EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with A549 cells[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; 50mg/kg; from 14 days; once per day
Result: Had strong anti-tumorigenic effects in tumor xenografts.

分子量

217.26

Formula

C13H15NO2

CAS 号

2094547-67-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

溶解性数据
In Vitro: 

DMSO : 5 mg/mL (23.01 mM; Need ultrasonic)

Ethanol : 2 mg/mL (9.21 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.6028 mL 23.0139 mL 46.0278 mL
5 mM 0.9206 mL 4.6028 mL 9.2056 mL
10 mM 0.4603 mL 2.3014 mL 4.6028 mL

*

请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用

参考文献
  • [1]. Counihan JL,et al.Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.ACS Chem Biol. 2018 Aug 17;13(8):1970-1977

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