2-Iodomelatonin(Synonyms: 2-碘褪黑激素)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Iodomelatonin (Synonyms: 2-碘褪黑激素) 纯度: ≥99.0%

2-Iodomelatonin 是褪黑激素受体 1 (MT1) 的强效激动剂，Ki  为 28 pM，对 MT1的选择性是 MT2 的 5 倍以上。2-Iodomelatonin 可用于鉴定，表征和定位脑和周围组织的褪黑激素结合位点。

2-Iodomelatonin(Synonyms: 2-碘褪黑激素)

2-Iodomelatonin Chemical Structure

CAS No. : 93515-00-5

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1655 询价
1 mg ￥700 In-stock
5 mg ￥2100 询价
10 mg ￥3600 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

2-Iodomelatonin 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Anti-Cancer Compound Library

生物活性

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1  over MT2[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues[1].

体外研究
(In Vitro)

2-iodomelatonin (0-7.5 μM; 18 hours) shares the protective properties of melatonin, it inhibits cell death of mutant htt ST14A and inhibits the increase in Rip2 expression in stressed mutant htt ST14A cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Mutant htt ST14A cell
Concentration: 0 μM; 1 μM; 5 μM; 7.5 μM
Incubation Time: 18 hours
Result: Inhibited mutant htt ST14A cell death.

分子量

358.17

Formula

C13H15IN2O2
CAS 号

93515-00-5
中文名称

2-碘褪黑激素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMF : 30 mg/mL (83.76 mM; Need ultrasonic and warming)

DMSO : 30 mg/mL (83.76 mM; Need ultrasonic and warming)

Ethanol : 20 mg/mL (55.84 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7920 mL 13.9599 mL 27.9197 mL
5 mM 0.5584 mL 2.7920 mL 5.5839 mL
10 mM 0.2792 mL 1.3960 mL 2.7920 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Tomkinson A, et al. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol. 2001 May 1;166(9):5792-800.

    [2]. Wang X, et al. The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.J Neurosci. 2011 Oct 12;31(41):14496-507.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务