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Ligustilide (Synonyms: 蒿本内酯) 纯度: 98.07%
Ligustilide 是从当归和川芎中分离出来的一种生物活性邻苯二甲酸酯衍生物。Ligustilide 具有神经保护,抗癌,抗炎和血管扩张作用。
Ligustilide Chemical Structure
CAS No. : 4431-01-0
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥800 | In-stock | |
5 mg | ¥1800 | In-stock | |
10 mg | ¥2800 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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生物活性 |
Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects[1][2][3]. |
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体外研究 (In Vitro) |
Pretreatment with Ligustilide (1 μM, 5 μM, 15 μM) significantly improves cell viability. The apoptosis rate in glutamate-induced PC12 cells is 13.39%, and decreased in the presence of Ligustilide (1 μM, 5 μM, 15 μM) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate are significantly reduced by Ligustilide. Pretreatment Ligustilide could decrease the release of cytochrome C from mitochondria, down-regulate Caspase-3 protein expression and up-regulate Bcl-2/Bax ratio, thereby protects PC12 cells from apoptosis[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
190.24 |
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Formula |
C12H14O2 |
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CAS 号 |
4431-01-0 |
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中文名称 |
蒿本内酯 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
-20°C, protect from light, stored under nitrogen *该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (525.65 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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