Salbutamol hemisulfate(Synonyms: 沙丁胺醇半硫酸盐; Albuterol hemisulfate; AH-3365 hemisulfate)

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Salbutamol hemisulfate (Synonyms: 沙丁胺醇半硫酸盐; Albuterol hemisulfate; AH-3365 hemisulfate) 纯度: ≥98.0%

Salbutamol Hemisulfate (Albuterol hemisulfate) 是短效的β2肾上腺素受体激动剂。

Salbutamol hemisulfate(Synonyms: 沙丁胺醇半硫酸盐; Albuterol hemisulfate; AH-3365 hemisulfate)

Salbutamol hemisulfate Chemical Structure

CAS No. : 51022-70-9

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in Water ￥715 In-stock
100 mg ￥650 In-stock
500 mg ￥1500 In-stock
1 g   询价  
5 g   询价  

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生物活性

Salbutamol Hemisulfate (Albuterol hemisulfate) is a short-acting β2 adrenergic receptor agonist Target: β2 Adrenergic Receptor Salbutamol Hemisulfate (Albuterol hemisulfate) is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. All the effects of R,S-salbutamol on guinea-pig skeletal muscles are due to the activity of the R-enantiomer. Thus there is a common enantiomeric profile for the skeletal muscle and bronchorelaxant activity of the compound [1]. Short-term Salbutamol intake did appear to improve performance during intense submaximal exercise with concomitant increase in substrate availability and utilization, but the exact mechanisms involved need further investigation [2]. Short-term administration of salbutamol increases voluntary muscle strength in man. However, the magnitude and duration of this effect vary between muscle groups. This study implies that the beta 2-adrenoceptor agonists may be of therapeutic potential in altering skeletal muscle function in humans [3].

Clinical Trial

分子量

288.14

Formula

C13H22NO5S0.5
CAS 号

51022-70-9
中文名称

沙丁胺醇半硫酸盐；羟甲叔丁肾上腺素半硫酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 100 mg/mL (347.05 mM; Need ultrasonic)

DMSO : 2 mg/mL (6.94 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4705 mL 17.3527 mL 34.7053 mL
5 mM 0.6941 mL 3.4705 mL 6.9411 mL
10 mM 0.3471 mL 1.7353 mL 3.4705 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Prior, C., M.B. Leonard, and J.R. McCullough, Effects of the enantiomers of R,S-salbutamol on incompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig. Br J Pharmacol, 1998. 123(3): p. 558-64.

    [2]. Collomp, K., et al., Effects of short-term oral salbutamol administration on exercise endurance and metabolism. J Appl Physiol (1985), 2000. 89(2): p. 430-6.

    [3]. Martineau, L., et al., Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men. Clin Sci (Lond), 1992. 83(5): p. 615-21.

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