Boc-NH-C4-Br

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Boc-NH-C4-Br 

Boc-NH-C4-Br 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

Boc-NH-C4-Br

Boc-NH-C4-Br Chemical Structure

CAS No. : 164365-88-2

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生物活性

Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

252.15

Formula

C9H18BrNO2

CAS 号

164365-88-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Hu R, et, al. Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor. Eur J Med Chem. 2022 Jan 5;227:113922.

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