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(S)-Crizotinib 纯度: 99.61%
(S)-Crizotinib 是一种有效的选择性 MTH1 (mutT 同源物)抑制剂,IC50 为 330 nM。(S)-Crizotinib 通过抑制 MTH1 破坏核苷酸库的稳态,诱导 DNA 单链断裂的增加,激活人结肠癌细胞的 DNA 修复,并有效抑制动物模型中的肿瘤生长。
(S)-Crizotinib Chemical Structure
CAS No. : 1374356-45-2
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥880 | In-stock | |
5 mg | ¥800 | In-stock | |
10 mg | ¥1200 | In-stock | |
50 mg | ¥2900 | In-stock | |
100 mg | ¥4500 | In-stock | |
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(S)-Crizotinib 相关产品
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生物活性 |
(S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC50 of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models[1]. |
IC50 & Target |
IC50: 330 nM (MTH1)[1] |
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体外研究 (In Vitro) |
(S)-crizotinib (0.625-80 μM; 24 hours) 降低了 NCI-H460,H1975 和 A549 细胞的活力,IC50 值分别为 14.29、16.54 和 11.25 μM[2]。 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[2]
Apoptosis Analysis[2]
Western Blot Analysis[2]
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体内研究 (In Vivo) |
(S)-crizotinib (7.5 或 15 mg/kg;腹腔注射;每天一次,连续10天)可显着降低肿瘤体积和肿瘤重量[2]。 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
450.34 |
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Formula |
C21H22Cl2FN5O |
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CAS 号 |
1374356-45-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 12.5 mg/mL (27.76 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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