上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
XL177A 纯度: 98.63%
XL177A 是一种高效选择性的不可逆 USP7 抑制剂,IC50 为 0.34 nM。XL177A 通过 p53 依赖性机制引发癌杀伤细胞作用。
![XL177A Chemical Structure XL177A](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-138794.gif)
XL177A Chemical Structure
CAS No. : 2417089-74-6
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥4800 | In-stock | |
10 mg | ¥8000 | In-stock | |
25 mg | ¥16500 | In-stock | |
50 mg | ¥26000 | In-stock | |
100 mg | ¥40000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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XL177A 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Cell Cycle/DNA Damage Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Ubiquitination Compound Library
- Targeted Diversity Library
生物活性 |
XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. XL177A elicits cancer cell killing through a p53-dependent mechanism[1]. |
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体外研究 (In Vitro) |
XL177A is a potent USP7 inhibitor and p53 stabilizer in cyto. XL177A suppresses cancer cell growth predominantly through a p53-dependent mechanism. XL177A labels the catalytic cysteine, C223, of USP7 with exquisite selectivity for USP7 across the DUBome and human proteome[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
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分子量 |
861.47 |
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Formula |
C48H57ClN8O5 |
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CAS 号 |
2417089-74-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 25 mg/mL (29.02 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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