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PD 407824 纯度: ≥98.0%
PD 407824 是一个检查点激酶 Chk1 和 WEE1 抑制剂,IC50分别为 47 和 97 nM。PD 407824 是一种化学 BMP 敏化剂,可提高细胞对亚阈值量的 BMP4 的敏感性。
PD 407824 Chemical Structure
CAS No. : 622864-54-4
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥903 | In-stock | |
1 mg | ¥500 | In-stock | |
5 mg | ¥1250 | In-stock | |
10 mg | ¥2300 | In-stock | |
25 mg | ¥4400 | In-stock | |
50 mg | ¥7500 | In-stock | |
100 mg | ¥13000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
PD 407824 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Cell Cycle/DNA Damage Compound Library
- Immunology/Inflammation Compound Library
- Kinase Inhibitor Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
生物活性 |
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
PD 407824 is sufficient to block CHK1, leading to a significant down-regulation of p21, causing activation of CDK8/9, which in turn causes depletion of SMAD2/3[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
328.32 |
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Formula |
C20H12N2O3 |
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CAS 号 |
622864-54-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 250 mg/mL (761.45 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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