Bergenin(Synonyms: 岩白菜素; Cuscutin)

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Bergenin (Synonyms: 岩白菜素; Cuscutin) 纯度: 99.63%

Bergenin 是一种细胞保护和抗氧化多酚在许多药用植物中发现。Bergenin 具有广泛的保肝、抗炎、免疫调节、抗肿瘤、抗病毒以及抗真菌作用。

Bergenin(Synonyms: 岩白菜素; Cuscutin)

Bergenin Chemical Structure

CAS No. : 477-90-7

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生物活性

Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties[1][2].

体外研究
(In Vitro)

Bergenin (7.5-30µM; 24 hours) decreases the viability of HeLa cervical cancer cells (IC50=15 µM)[1].
Bergenin (7.5-30 µM; 24 hours) induces apoptosis in HeLa cervical cancer cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HeLa cervical cancer cells
Concentration: 7.5, 15, 30 µM
Incubation Time: 24 hours
Result: Decreased the viability of HeLa cervical cancer cells.

Cell Viability Assay[1]

Cell Line: HeLa cervical cancer cells
Concentration: 7.5, 15, 30 µM
Incubation Time: 24 hours
Result: Induced apoptosis in HeLa cervical cancer cells.

体内研究
(In Vivo)

Pretreatment with Bergenin (12.5-100 mg/kg; i.p.; once) produces a dose-related inhibition of acetic acid-induced writhing in mice[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster C57BL/6 mice[3]
Dosage: 12.5, 25, 50, 100 mg/kg
Administration: i.p.; Once
Result: Produced a dose-related inhibition of acetic acid-induced writhing in mice.

分子量

328.27

Formula

C14H16O9
CAS 号

477-90-7
中文名称

岩白菜素；矮茶素；佛手配质；岩白菜宁；虎耳草素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (304.63 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0463 mL 15.2314 mL 30.4627 mL
5 mM 0.6093 mL 3.0463 mL 6.0925 mL
10 mM 0.3046 mL 1.5231 mL 3.0463 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.62 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.62 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.62 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Shi X, et al. Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway. Exp Ther Med. 2019 May;17(5):3525-3529.

    [2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54.

    [3]. de Oliveira CM, et al. Antinociceptive properties of bergenin. J Nat Prod. 2011 Oct 28;74(10):2062-8.

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