上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
C527 纯度: 99.88%
C527是泛 DUB 酶的抑制剂,对 USP1/UAF1 复合物活性较高, IC50 值为0.88 μM。
![C527 Chemical Structure C527](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-12988.gif)
C527 Chemical Structure
CAS No. : 192718-06-2
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥600 | In-stock | |
10 mg | ¥1000 | In-stock | |
25 mg | ¥2100 | In-stock | |
50 mg | ¥3500 | In-stock | |
100 mg | ¥5900 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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C527 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
生物活性 |
C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM). |
IC50 & Target |
0.88 μM (USP1)[1] |
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体外研究 (In Vitro) |
Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro. However, the IC50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
293.25 |
Formula |
C17H8FNO3 |
CAS 号 |
192718-06-2 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
溶解性数据 |
In Vitro:
H2O : < 0.1 mg/mL (insoluble) DMSO : < 1 mg/mL (insoluble or slightly soluble) |
参考文献 |
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Cell Assay [1] |
HeLa cells are treated with DMSO or C527 (0.5, 1, 5 μM) in appropriate medium for 24 to 72 hours. The viable cell counts are determined using Trypan Blue staining, CellTiter-Glo reagent or MTT assay[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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