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BMS-1166 纯度: 98.37%
BMS-1166 是一种有效的 PD-1/PD-L1 免疫检查点抑制剂。BMS-1166 诱导 PD-L1 二聚化并阻断其与 PD-1 的相互作用,IC50 为 1.4 nM。BMS-1166 拮抗 PD-1/PD-L1 免疫检查点对 T 细胞活化的抑制作用。
BMS-1166 Chemical Structure
CAS No. : 1818314-88-3
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥2530 | In-stock | |
5 mg | ¥2300 | In-stock | |
10 mg | ¥3800 | In-stock | |
25 mg | ¥7100 | In-stock | |
50 mg | ¥13000 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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BMS-1166 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Immunology/Inflammation Compound Library
- Anti-Cancer Compound Library
- Small Molecule Immuno-Oncology Compound Library
- Peptidomimetic Library
- Anti-Breast Cancer Compound Library
- Anti-Lung Cancer Compound Library
- Anti-Blood Cancer Compound Library
- Targeted Diversity Library
- Anti-Liver Cancer Compound Library
- Anti-Colorectal Cancer Compound Library
生物活性 |
BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2]. |
IC50 & Target |
IC50: 1.4 nM (PD-1/PD-L1 interaction)[1]. |
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体外研究 (In Vitro) |
BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
641.11 |
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Formula |
C36H33ClN2O7 |
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CAS 号 |
1818314-88-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (194.97 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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