上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
CP-10 纯度: 98.03%
CP-10 是由Cereblon配体和CDK配体相连的PROTAC,具有高选择性,特异性和显著的 CDK6 降解潜力 (DC50=2.1 nM) 的 PROTAC。它抑制几种造血细胞癌的增殖,包括多发性骨髓瘤,并且对突变和过表达的 CDK6 仍然可以降解。
CP-10 Chemical Structure
CAS No. : 2366268-80-4
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥8800 | In-stock | |
10 mg | ¥12500 | In-stock | |
50 mg | ¥26500 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
CP-10 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
生物活性 |
CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
871.94 |
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Formula |
C44H49N13O7 |
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CAS 号 |
2366268-80-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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溶解性数据 |
In Vitro:
DMSO : 200 mg/mL (229.37 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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