CCR7 Ligand 1(Synonyms: CCR7-Cmp2105)

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CCR7 Ligand 1 (Synonyms: CCR7-Cmp2105) 纯度: 99.64%

CCR7 Ligand 1 (CCR7-Cmp2105) 是人 CC 趋化因子受体 7 (CCR7) 的变构配体，也是有效的 CCR7 拮抗剂，Kd 值为 3 nM。CCR7 Ligand 1 是一种噻二唑-二氧化物配体，可抑制蛋白与 CCL19 激活反应结合，IC50 为 7.3 μM。

CCR7 Ligand 1(Synonyms: CCR7-Cmp2105)

CCR7 Ligand 1 Chemical Structure

CAS No. : 681514-83-0

规格 价格 是否有货 数量
5 mg ￥5950 In-stock
10 mg ￥9500 In-stock
50 mg ￥29500 In-stock
100 mg   询价  
200 mg   询价  

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CCR7 Ligand 1 相关产品

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生物活性

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1].

IC50 & Target[1]

Human CCR7

3 nM (Kd)

体外研究
(In Vitro)

CCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8[1].
CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM[1].
CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

475.56

Formula

C22H29N5O5S
CAS 号

681514-83-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (210.28 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1028 mL 10.5139 mL 21.0278 mL
5 mM 0.4206 mL 2.1028 mL 4.2056 mL
10 mM 0.2103 mL 1.0514 mL 2.1028 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Jaeger K, et al. Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7. Cell. 2019 Aug 22;178(5):1222-1230.e10.

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