上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
AZ82 纯度: 99.20%
AZ82 是一种驱动蛋白样蛋白 KIFC1 (HSET/KIFC1) 的选择性抑制剂,其 Ki 值和 IC50 值分别为 43 nM 和 300 nM。
AZ82 Chemical Structure
CAS No. : 1449578-65-7
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥2960 | In-stock | |
5 mg | ¥2400 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
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AZ82 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
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- Anti-Cancer Compound Library
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- Cytoskeleton Compound Library
- Anti-Breast Cancer Compound Library
- Targeted Diversity Library
生物活性 |
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. |
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IC50 & Target[1][2] |
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体外研究 (In Vitro) |
AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa[1]. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes with an IC50 of 0.90 ± 0.09 μM for mant-ATP binding and 1.26 ± 0.51 μM for mant-ADP releasing[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
560.63 |
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Formula |
C28H31F3N4O3S |
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CAS 号 |
1449578-65-7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (222.96 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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