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GOT1 inhibitor-1 纯度: 99.51%
GOT1 inhibitor-1 (compound 2c) 是一种戊酸衍生物,是一种新型的、有效的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂,IC50 为 8.2 uM。 GOT1 inhibitor-1 可用于胰腺导管腺癌 (PDAC) 的研究。
![GOT1 inhibitor-1 Chemical Structure GOT1 inhibitor-1](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-122723.gif)
GOT1 inhibitor-1 Chemical Structure
CAS No. : 732973-87-4
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥2750 | In-stock | |
5 mg | ¥2500 | In-stock | |
10 mg | ¥4000 | In-stock | |
25 mg | ¥7500 | In-stock | |
50 mg | ¥11000 | In-stock | |
100 mg | ¥15500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
GOT1 inhibitor-1 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Anti-Cancer Compound Library
- Targeted Diversity Library
生物活性 |
GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC)[1]. |
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体外研究 (In Vitro) |
PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research. In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC50 value of 8.2 uM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
354.83 |
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Formula |
C19H19ClN4O |
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CAS 号 |
732973-87-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (352.28 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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