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WDR5-0103 (Synonyms: WD-Repeat Protein 5-0103) 纯度: 98.11%
WDR5-0103是一个有效的含WD重复序列蛋白5 (WDR5) 选择性拮抗剂, Kd值为450 nM。
WDR5-0103 Chemical Structure
CAS No. : 890190-22-4
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥792 | In-stock | |
5 mg | ¥720 | In-stock | |
10 mg | ¥1200 | In-stock | |
50 mg | ¥5000 | In-stock | |
100 mg | ¥8000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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WDR5-0103 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Epigenetics Compound Library
- Histone Modification Research Compound Library
- Anti-Cancer Compound Library
- Anti-Blood Cancer Compound Library
- Targeted Diversity Library
生物活性 |
WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM. IC50 value: 450 nM (Kd) Target: WDR5 in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5. |
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分子量 |
383.44 |
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Formula |
C21H25N3O4 |
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CAS 号 |
890190-22-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (130.40 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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