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W-7 hydrochloride 纯度: 99.65%
W-7 hydrochloride 是一种选择性的钙调蛋白 (calmodulin) 拮抗剂。W-7 hydrochloride 抑制 Ca2+-钙调蛋白依赖性磷酸二酯酶 (phosphodiesterase) 和肌球蛋白轻链激酶 (myosin light chain kinase),IC50 值分别为 28 μM 和 51 μM。W-7 hydrochloride 可诱导细胞凋亡 (apoptosis),并具有抗癌活性。
W-7 hydrochloride Chemical Structure
CAS No. : 61714-27-0
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1980 | In-stock | |
25 mg | ¥1800 | In-stock | |
50 mg | ¥2700 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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W-7 hydrochloride 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
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- Metabolism/Protease Compound Library
- Neuronal Signaling Compound Library
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- Anti-Alzheimer’s Disease Compound Library
- Anti-Blood Cancer Compound Library
- Neurodegenerative Disease-related Compound Library
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生物活性 |
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 µM, respectively[1][2]. W-7 hydrochloride induces apoptosis and has antitumor activity[3]. |
IC50 & Target |
IC50: 28 μM (Phosphodiesterase) and 51 µM (Myosin light chain kinase)[1] |
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体外研究 (In Vitro) |
W-7 is distributed mainly in the cytoplasm, and inhibits proliferation of Chinese hamster ovary K1 (CHO-K1) cells. W-7 selectively blocks the phase of the cell cycle (G1/S boundary phase) in a manner. 25 μM W-7 arrests the growth of the cells at the G1/S boundary phase of the cell cycle[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
W-7 (3 mg/kg; intraperitoneal injection; on 5 consecutive days per week; female BALB/c nu mice) treatment significantly reduces tumor growth in a murine MM model[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
377.33 |
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Formula |
C16H22Cl2N2O2S |
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CAS 号 |
61714-27-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 250 mg/mL (662.55 mM; Need ultrasonic) H2O : 1.43 mg/mL (3.79 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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