Dihydroisotanshinone I(Synonyms: 二氢异丹参酮I)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Dihydroisotanshinone I (Synonyms: 二氢异丹参酮I) 纯度: 99.52%

Dihydroisotanshinone I 是丹参中的一种生物活性化合物，可抑制雄激素依赖性和雄激素非依赖性前列腺癌细胞的迁移。Dihydroisotanshinone I 还诱导这些肺癌细胞的凋亡 (apoptosis) 和铁死亡 (ferroptosis)。Dihydroisotanshinone I 还阻断 GPX4 的蛋白表达。

Dihydroisotanshinone I(Synonyms: 二氢异丹参酮I)

Dihydroisotanshinone I Chemical Structure

CAS No. : 20958-18-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2380 In-stock
5 mg ￥1800 In-stock
10 mg ￥2800 In-stock
25 mg ￥5800 In-stock
50 mg ￥9800 In-stock
100 mg   询价  
200 mg   询价  

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Dihydroisotanshinone I 相关产品

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生物活性

Dihydroisotanshinone I, a bioactive compound present in danshen, can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone I also induces apoptosis and ferroptosis in these lung cancer cells. Dihydroisotanshinone I also blocks the protein expression of GPX4[1][2].

IC50 & Target[1]

STAT3

 

体外研究
(In Vitro)

Dihydroisotanshinone I inhibits the protein expression of p-STAT3 and blocked the translocation of STAT3 into the chromatin, as well as suppressed tumor epithelial–mesenchymal transition (EMT) gene expression[1].
Dihydroisotanshinone I (10-30 μM; 24 huors) has inhibitory effects on the growth of the lung cancer cell lines, A549 cells and H460 cells[2].
Dihydroisotanshinone I (20-30 μM; 24 huors) induces pronounced apoptosis in A549 and H460 cells in a dose-dependent manner[2].
Dihydroisotanshinone I can induce ferroptosis in lung cancer cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Dihydroisotanshinone I (30 mg/kg; intraperitoneally; every 2 days for 18 days) can inhibit metastasis of A549 cells in the nude mice model without adverse effects on mice[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (beraing A549 cells) [2]
Dosage: 30 mg/kg
Administration: Intraperitoneally; every 2 days for 18 days
Result: Inhibited A549 cell metastasis in nude mice without adverse effects.

分子量

278.30

Formula

C18H14O3
CAS 号

20958-18-3
中文名称

二氢异丹参酮I
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 3.33 mg/mL (11.97 mM; ultrasonic and warming and heat to 40°C)

H2O : 1 mg/mL (3.59 mM; ultrasonic and warming and heat to 80°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5932 mL 17.9662 mL 35.9324 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL
10 mM 0.3593 mL 1.7966 mL 3.5932 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

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