Bax activator-1

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Bax activator-1 

Bax activator-1 (compound 106) 是一种 Bax 激活剂，诱导 Bax 依赖性肿瘤细胞凋亡。

Bax activator-1

Bax activator-1 Chemical Structure

CAS No. : 1638526-94-9

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生物活性

Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis[1].

IC50 & Target

Bax

 

体外研究
(In Vitro)

Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells
Concentration: 20 μM, 40 μM , 60 μM , 80 μM
Incubation Time: 48 hours
Result: Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion.

体内研究
(In Vivo)

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)[1]
Dosage: 40 mg/kg
Administration: Given i.p., each day for 13 days
Result: Exhibited anti-tumor activity as a single-agent.

分子量

488.62

Formula

C29H36N4O3
CAS 号

1638526-94-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhao G, et al. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Mol Cell Biol. 2014 Apr;34(7):1198-207.

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