Phen-DC3

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Phen-DC3 

Phen-DC3 是一个 G4 特异性配体，可以抑制解旋酶 FANCJ 和 DinG 且 IC50s 值分别为 65±6 和 50±10 nM。

Phen-DC3

Phen-DC3 Chemical Structure

CAS No. : 942936-75-6

规格 是否有货
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Phen-DC3 的其他形式现货产品:

Phen-DC3 Trifluoromethanesulfonate

生物活性

Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.

IC50 & Target

IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)[1].
分子量

550.61

Formula

C34H26N6O22+
CAS 号

942936-75-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

DMSO : ≥ 34 mg/mL (61.75 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8162 mL 9.0808 mL 18.1617 mL
5 mM 0.3632 mL 1.8162 mL 3.6323 mL
10 mM 0.1816 mL 0.9081 mL 1.8162 mL

参考文献

  • [1]. Bharti SK, et al. Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem. 2013 Sep 27; 288(39):28217-29.

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