ACTH (1-14)(Synonyms: Adrenocorticotropic Hormone Fragment 1-14)

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ACTH (1-14) (Synonyms: Adrenocorticotropic Hormone Fragment 1-14)

ACTH (1-14) 是促肾上腺皮质激素的多肽片段，后者能够促进皮质醇的释放。

ACTH (1-14)(Synonyms: Adrenocorticotropic Hormone Fragment 1-14)

ACTH (1-14) Chemical Structure

CAS No. : 25696-21-3

规格 是否有货
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ACTH (1-14) 的其他形式现货产品:

ACTH (1-14) (TFA)

生物活性

ACTH (1-14) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.

体外研究
(In Vitro)

Adrenocorticotropic hormone (ACTH) is a tropic hormone produced by the anterior pituitary, regulates cortisol and androgen production and is associated with Addison disease, Cushing syndrome and Cushing disease[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1680.88

Formula

C77H109N21O20S
CAS 号

25696-21-3
Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly
Sequence Shortening

SYSMEHFRWGKPVG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Mulabegović N, et al. Pharmacodynamic properties of a combination of met-enkephalin and alpha 1-13 adrenocorticotropic hormone. Med Arh. 2008;62(1):41-4.

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