DDR1-IN-1 dihydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DDR1-IN-1 dihydrochloride 

DDR1-IN-1 dihydrochloride是DDR1受体酪氨酸激酶抑制剂，IC50 值为105 nM，而对 DDR2 的 IC50 为413 nM。

DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride Chemical Structure

CAS No. : 1780303-76-5

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DDR1-IN-1 dihydrochloride 的其他形式现货产品:

DDR1-IN-1

生物活性

DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM)[1].

IC50 & Target

DDR1

105 nM (IC50)

DDR2

413 nM (IC50)

体外研究
(In Vitro)

DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

625.51

Formula

C30H33Cl2F3N4O3
CAS 号

1780303-76-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8(10):2145-50.

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