NAMPT inhibitor-linker 1 | whatman (沃特曼)

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NAMPT inhibitor-linker 1

NAMPT inhibitor-linker 1 为 ADC 的一部分，由一种 NAMPT 的抑制剂作为有效载荷和一个连接物组成。ADC-3 由一个 NAMPT inhibitor-linker 1 和一个 anti-c-Kit 单克隆抗体组成，对表达 c-Kit 的细胞具有抑制作用，比如 GIST-T1 和 NCI-H526 细胞，IC₅₀ 值分别为 <3 pM 和 9 pM。

NAMPT inhibitor-linker 1 Chemical Structure

CAS No. : 2241019-57-6

规格		是否有货
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生物活性

NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC₅₀s of <3 pM and 9 pM, respectively.

IC₅₀ & Target

Traditional Cytotoxic Agents

体外研究
(In Vitro)

ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC₅₀s of <3 pm and 9 pm, respectively^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female scid-beige (SCID bg) mice^[1]
Dosage:	20 mg/kg
Administration:	A single intravenous injection (i.v.) for 28 days
Result:	Significantly inhibited the growth of tumor in mice.

分子量

668.71

Formula

C₃₆H₃₇FN₆O₆

CAS 号

2241019-57-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

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