Lucanthone-d4 hydrochloride

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Lucanthone-d4 hydrochloride 

Lucanthone-d4 hydrochloride 是 Lucanthone 的氘代物。Lucanthone 是 Apurinic 内切核酸酶-1 (APE-1) 的内切核酸酶抑制剂。

Lucanthone-d4 hydrochloride

Lucanthone-d4 hydrochloride Chemical Structure

CAS No. : 1329613-40-2

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生物活性

Lucanthone-d4 hydrochloride is the deuterium labeled Lucanthone. Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1)[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

380.97

Formula

C20H21D4ClN2OS
CAS 号

1329613-40-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18.

    [3]. Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.

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