1-Hydroxyanthraquinone(Synonyms: 1-羟基蒽醌)

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1-Hydroxyanthraquinone (Synonyms: 1-羟基蒽醌) 纯度: 98.77%

1-Hydroxyanthraquinone 是具有口服活性的天然产物，可来源于一些植物如 Tabebuia avellanedae，具有致癌作用。

1-Hydroxyanthraquinone(Synonyms: 1-羟基蒽醌)

1-Hydroxyanthraquinone Chemical Structure

CAS No. : 129-43-1

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10 mM * 1 mL in DMSO ￥550 In-stock
500 mg ￥500 In-stock
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生物活性

1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1].

体内研究
(In Vivo)

1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Thirty rats[1].
Dosage: 1% HA in diet.
Administration: Diet.
Result: Associated with decreased weight gain which was particularly marked towards the termination of experiment.
One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment.
A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon.
Seven animals of the group died spontaneously or were sacrificed upon becoming moribund between 335 and 462 days.
A total of 21 rats of group 1 survived until the end of experiment (mean value of total intake of HA/rat was 76.8 g).

分子量

224.21

Formula

C14H8O3
CAS 号

129-43-1
中文名称

1-羟基蒽醌
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 16.67 mg/mL (74.35 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.4601 mL 22.3005 mL 44.6010 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL
10 mM 0.4460 mL 2.2301 mL 4.4601 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802.

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