上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Allitinib (Synonyms: AST-1306; ALS 1306)
Allitinib (AST-1306) 是一种具有口服活性且不可逆的 EGFR 和 ErbB2 抑制剂,IC50 分别为 0.5 和 3 nM。Allitinib 抑制 ErbB4,IC50 为 0.8 nM。Allitinib 是一种苯胺基喹唑啉化合物,具有抗癌活性。
Allitinib Chemical Structure
CAS No. : 897383-62-9
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Allitinib 的其他形式现货产品:
生物活性 |
Allitinib (AST-1306) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. Allitinib also inhibits ErbB4 with an IC50 of 0.8 nM. Allitinib is an anilino-quinazoline compound and has anti-cancer activity[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
AST1306 (AST-1306; 0.19-6.25 μM; 72 hours) induces a significant, concentration-dependent inhibition of the growth of HIH3T3-EGFR T790M/L858R cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) |
AST1306 (AST-1306; p.o.; 25-100 mg/kg; twice daily; for 28 days) causes a dramatic suppression of tumor growth in SK-OV-3 and Calu-3 xenograft models[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
448.88 |
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Formula |
C24H18ClFN4O2 |
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CAS 号 |
897383-62-9 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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