TH588 hydrochloride | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TH588 hydrochloride

TH588 盐酸盐是 MTH1 (NUDT1) 高效选择性抑制剂，IC₅₀ 值 5 nM。

TH588 hydrochloride Chemical Structure

CAS No. : 1640282-30-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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TH588 hydrochloride 的其他形式现货产品:

TH588

生物活性

TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC₅₀= 5 nM).

体外研究
(In Vitro)

TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC₅₀s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM ^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells
Concentration:	2, 4, 6, 8, 10 μM
Incubation Time:	7–10 days
Result:	Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC₅₀s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, respectively, but was less toxic to several primary or immortalized cells.

体内研究
(In Vivo)

TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5-6 weeks female SCID mice (SW480 xenograft cancer model)^[1]
Dosage:	30 mg/kg
Administration:	Subcutaneous injection (s.c.); once daily for 35 days
Result:	Reduced tumour growth in SW480 xenograft cancer model.

分子量

331.63

Formula

C₁₃H₁₃Cl₃N₄

CAS 号

1640282-30-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.

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