(Rac)-IBT6A hydrochloride

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(Rac)-IBT6A hydrochloride 

(Rac)-IBT6A hydrochloride 是 IBT6A hydrochloride 的消旋体。IBT6A 是 Ibrutinib 的一种杂质。IBT6A 可用于合成 IBT6A-Ibrutinib 二聚体和 IBT6A 加合物。Ibrutinib 是一种不可逆的选择性 Btk 抑制剂，IC50 为 0.5 nM。

(Rac)-IBT6A hydrochloride

(Rac)-IBT6A hydrochloride Chemical Structure

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(Rac)-IBT6A hydrochloride 的其他形式现货产品:

(Rac)-IBT6A IBT6A IBT6A hydrochloride

生物活性

(Rac)-IBT6A hydrochloride is a racemate of IBT6A hydrochloride. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].

体外研究
(In Vitro)

IBT6A (Compound 14) can be used in synthesis of Ibrutinib and Ibrutinib-based activity-based probes (ABPs)[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

422.91

Formula

C22H23ClN6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.

    [2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

    [3]. Liu N, et al. Direct and two-step bioorthogonal probes for Bruton’s tyrosine kinase based on ibrutinib: a comparative study. Org Biomol Chem. 2015 May 14;13(18):5147-57.

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