Arecoline(Synonyms: 槟榔碱)

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Arecoline (Synonyms: 槟榔碱)

Arecoline，一种天然生物碱，是烟碱和毒蕈碱乙酰胆碱受体的部分激动剂。Arecoline 具有刺激、警觉、抗焦虑和抗寄生虫作用。Arecoline 也可以诱导氧化应激。

Arecoline(Synonyms: 槟榔碱)

Arecoline Chemical Structure

CAS No. : 63-75-2

规格 价格 是否有货
10 mg ￥350 询问价格 & 货期
50 mg ￥770 询问价格 & 货期

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Arecoline 的其他形式现货产品:

Arecoline hydrobromide

生物活性

Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress[1][2][3][4].

IC50 & Target

nAChR/mAChR[3]
体外研究
(In Vitro)

Arecoline induces the generation of reactive oxygen species and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting the expression of p21/Cip1. Arecoline-induced epithelial cell death at higher concentrations is caused by oxidative trauma without eliciting apoptosis. Arecoline upregulates the expression of the following stress-responsive genes: hemeoxygenase-1; ferritin light chain; glucose-6-phosphate dehydrogenase; glutamatecysteine ligase catalytic subunit; and glutathione reductase[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

155.19

Formula

C8H13NO2
CAS 号

63-75-2
中文名称

槟榔碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. G S Thangjam, et al. Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. J Periodontal Res. 2009 Oct;44(5):673-82.

    [2]. Liu YJ, et, al. The pharmacology, toxicology and potential applications of arecoline: a review. Pharm Biol. 2016 Nov;54(11):2753-2760.

    [3]. Volgin AD, et, al. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chem Neurosci. 2019 May 15;10(5):2176-2185.

    [4]. Kuo TM, et, al. Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells. J Biomed Sci. 2014 Sep 9;21(1):93.

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