Pifithrin-β(Synonyms: PFT β; Cyclic Pifithrin-α)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pifithrin-β (Synonyms: PFT β; Cyclic Pifithrin-α)

Pifithrin-β (PFT β) 是有效地 p53 抑制剂，IC50 值为 23 μM。

Pifithrin-β(Synonyms: PFT β; Cyclic Pifithrin-α)

Pifithrin-β Chemical Structure

CAS No. : 60477-34-1

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Pifithrin-β 的其他形式现货产品:

Pifithrin-β hydrobromide

生物活性

Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.

IC50 & Target

IC50: 23 μM (p53)[1]
体外研究
(In Vitro)

Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

268.38

Formula

C16H16N2S
CAS 号

60477-34-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57.

    [2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83.

    [3]. Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.

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