Raf inhibitor 1 dihydrochloride | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Raf inhibitor 1 dihydrochloride

B-Raf inhibitor 1 dihydrochloride 是一种有效的 Raf 激酶抑制剂，作用于 B-Raf^WT, B-Raf^V600E, 和 C-Raf, K_i 分别为 1 nM, 1 nM, 和 0.3 nM。

Raf inhibitor 1 dihydrochloride Chemical Structure

CAS No. : 1191385-19-9

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Raf inhibitor 1 dihydrochloride 的其他形式现货产品:

Raf inhibitor 1

生物活性

B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with K_is of 1 nM, 1 nM, and 0.3 nM for B-Raf^WT, B-Raf^V600E, and C-Raf, respectively.

IC₅₀ & Target^[1]

B-Raf

1 nM (Ki)

B-Raf^V600E

1 nM (Ki)

c-Raf

0.3 nM (Ki)

体外研究
(In Vitro)

B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC₅₀s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

551.86

Formula

C₂₆H₂₁Cl₃N₈

CAS 号

1191385-19-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wang X, et al. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41.

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