CDK4/6-IN-9 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK4/6-IN-9

CDK4/6-IN-9 (compound 10) 是一种选择性 CDK4/6 抑制剂，对 CDK6/cyclin D1 的 IC₅₀ 为 905 nM。CDK4/6-IN-9 具有用于多发性骨髓瘤 (MM) 研究的潜力。

CDK4/6-IN-9 Chemical Structure

CAS No. : 2688098-02-2

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生物活性

CDK4/6-IN-9 (compound 10) is a selective CDK4/6 inhibitor with an IC₅₀ of 905 nM for CDK6/cyclin D1. CDK4/6-IN-9 has the potential for multiple myeloma (MM) research^[1].

IC₅₀ & Target^[1]

CDK6/cyclinD1

905 nM (IC₅₀)

CDK4/cyclinD1

分子量

418.47

Formula

C₂₂H₂₃FN₈

CAS 号

2688098-02-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kai Yuan, et al. Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma. Eur J Med Chem. 2022 Jan 15;228:114024.

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