c-Met/MEK1/Flt-3-IN-1 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

c-Met/MEK1/Flt-3-IN-1

Antiproliferative against-3 (comp 33) 具有良好的抗癌细胞增殖活性，对 Hela、A549 和 MCF-7 的细胞的IC₅₀ 值分别为 0.21 µM、0.39 µM 和 0.33 µM。Antiproliferative against-3 (comp 33) 剂量依赖性的诱导A549 细胞的凋亡，并将细胞阻滞在 G1 期。

c-Met/MEK1/Flt-3-IN-1 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	Antiproliferative against-3 (comp 33) shows a prominent activity against Hela (IC₅₀ = 0.21 µM), A549 (IC₅₀ = 0.39 µM), and MCF-7 (IC₅₀ = 0.33 µM), respectively. Antiproliferative against-3 (comp 33) also dose dependently induces apoptosis by arresting A549 cells at G1 phase^[1].
分子量	688.75
Formula	C₃₉H₃₇FN₆O₅
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Pengqin Chen, et al. Design, synthesis and anticancer evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 1,8-naphthyridine-3-carboxamide moiety as novel multi-target TKIs. Bioorg Chem. 2022 Apr;121:105672.

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