SNIPER(TACC3)-11

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SNIPER(TACC3)-11 

SNIPER(TACC3)-11 是一种有效的成纤维细胞生长因子受体 3 转化酸性卷曲螺旋蛋白 3 (FGFR3-TACC3) 抑制剂。SNIPER(TACC3)-11 降低 FGFR3-TACC3 蛋白水平，抑制 FGFR3-TACC3 阳性癌细胞的生长。

SNIPER(TACC3)-11

SNIPER(TACC3)-11 Chemical Structure

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生物活性

SNIPER(TACC3)-11 is a potent FGFR3-TACC3 degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells[1].

IC50 & Target

FGFR3-TACC3[1]
体外研究
(In Vitro)

SNIPER(TACC3)-11 (compound 5a) (0.3-3 μM; 6 hours) reduces FGFR3-TACC3 levels[1].
SNIPER(TACC3)-11 (0.3-3 μM; 72 hours) inhibits the growth of RT4 cells at 3 µM, and does not inhibit the growth of HeLa cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line: RT4 cells[1]
Concentration: 0.3, 1 and 3 μM
Incubation Time: 6 hours
Result: Reduced FGFR3-TACC3 levels.

Cell Proliferation Assay

Cell Line: RT4 and HeLa cells[1]
Concentration: 0.3, 1 and 3 μM
Incubation Time: 72 hours
Result: Dramatically inhibited the growth of RT4 cells at 3 µM, and did not inhibit the growth of HeLa cells, which indicated that SNIPER(TACC3)-11 just inhibited the proliferation of cells expressing FGFR3-TACC3.

分子量

995.26

Formula

C51H66N10O7S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shibata N, Cho N, Koyama H, Naito M. Development of a degrader against oncogenic fusion protein FGFR3-TACC3. Bioorg Med Chem Lett. 2022;60:128584.

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