ALDH1A3-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ALDH1A3-IN-1 

ALDH1A3-IN-1 (Compound 14) 是一个有效的 ALDH1A3 抑制剂，其 IC50 值为 0.63 µM，Ki 值为 0.46 µM。ALDH1A3-IN-1 能被用于研究前列腺癌 (prostate cancer)。

ALDH1A3-IN-1

ALDH1A3-IN-1 Chemical Structure

CAS No. : 1695970-90-1

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生物活性

ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 µM and a Ki of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer[1].

IC50 & Target

ALDH1A3

0.63 μM (IC50)

ALDH1A1

7.08 μM (IC50)

ALDH3A1

8.00 μM (IC50)

ALDH1A3

0.46 μM (Ki)

ALDH1A3

26.92 μM (Km)

体外研究
(In Vitro)

ALDH1A3-IN-1 (Compound 14) (0-200 µM, 96 h) shows antiproliferative activity in prostate cancer cell lines[1].
ALDH1A3-IN-1 (0-200 µM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: PC3, LNCaP, and DU145 cells
Concentration: 12.5-200 µM
Incubation Time: 96 h
Result: Showed antiproliferative activity with IC50 values of 47 ± 6, 25 ± 1, and 61 ± 5 µM against PC3, LNCaP, and DU145 cells.

Cell Viability Assay[1]

Cell Line: Primary cells cultured at early passage from human prostate tissue biopsies
Concentration: 50 and 200 μM
Incubation Time: 72 h
Result: Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures.

分子量

284.19

Formula

C13H18BrNO
CAS 号

1695970-90-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ali I M Ibrahim, et al. Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer. J Med Chem. 2022 Mar 10;65(5):3833-3848.

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