Deac-SS-Biotin | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Deac-SS-Biotin

Deac-SS-Biotin 是一种有效的抗癌剂。Deac-SS-Biotin 通过生物素介导的内吞作用摄取进入细胞。Deac-SS-Biotin 与 DTT (谷胱甘肽) 结合可有效抑制微管组装并显示出更强的抗肿瘤活性。

Deac-SS-Biotin Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

Deac-SS-Biotin is a potent antitumor agent. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity^[1].

体外研究
(In Vitro)

Deac-SS-Biotin (compound 9) (5 µM; 24 h) has a remarkable reduction-responsive drug release^[1].
Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin^[1].
Deac-SS-Biotin (5 µM, 5 µM and 10 µM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	SGC-7901, A549, Hela, L929 cells
Concentration:	0-20 µM
Incubation Time:	72 h
Result:	Showed potent antiproliferative activity with IC₅₀s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells.

Cell Viability Assay^[1]

Cell Line:	A549 cells
Concentration:	0.17 µM
Incubation Time:
Result:	Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 µM.

分子量

763.94

Formula

C₃₅H₄₅N₃O₁₀S₃

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wang C,et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37(1):411-420.

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